Prosperi Lab

Welcome to our page!

Our lab is located at Indiana University School of Medicine - South Bend on the campus of the University of Notre Dame.

We are affiliated with the Harper Cancer Research Institute and the Melvin and Bren Simon Cancer Center.

The lab is broadly focused on the Wnt pathway independent functions of Adenomatous Polyposis Coli (APC). We are actively addressing 2 primary functions of APC:

1. How does loss of APC predict response to chemotherapy?

2. What is the role of APC in regulating early cellular changes that predispose cancer?

Home: Overview

Figure 2_Min vs Wt Proliferation and Apoptosis.portrait_edited_edited.jpg

APC and chemotherapy resistance in breast cancer

APC and early cellular changes

Personnel

Home: Research

Lab Accomplishments and Fun

Doxorubicin resistance paper

October 2017

Our paper describing the interaction between STAT3 and APC in mediating doxorubicin resistance was just accepted at Oncotarget.

Alyssa Lesko selected to present work at 2017 St. Jude's FFRC meeting

May 2017

Alyssa Lesko, a graduate student in the lab, was selected to present her work at the Future Fellow Research Conference (FFRC) at St. Jude's. This is a highly competitive opportunity, as students can only apply if they are pre-nominated.

Undergraduate Student Presentations!

Spring 2018

Our undergrads have been busy presenting their work at the Harper Research Day, Notre Dame's COS-JAM, and the annual AACR meeting! Click here for pictures!

Home: News & Resources